Cecilia Puga has undertaken different scale designs projects, such as family houses, social community housing, educational and industrial equipment, and urban design. Recent works by the studio include the Straits of Magellan Cruise Terminal and public infrastructure for the Queulat National Park in Patagonia.

She was a member of the Executive Committee of Fundación de la Familia Larrain Echenique (1999-2004) which is responsible for the Chilean Art Museum for Precolombian Art. Since 2020, she has been Director of the Chilean Museum of Pre-Columbian Art.

She is visiting professor in the Department of Architecture, Pontificia Universidá Católica de Chile (PUC), where she runs a foundation studio for second-year students. She was a visiting professor at the University of Texas (UT), Austin, USA (2007 and 2015), and was a speaker at the UT symposium Latitudes: Architecture in the Americas (2009). She was a visiting academic leading a design studio at the Harvard University Graduate School of Design (GSD) (2009) and Universitat Internacional de Catalunya in Barcelona (2011).

She studied architecture at PUC. In 2014 she won the International Architecture Competition “Palacio Pereira” for a new build and restoration project to create the new headquarters of the Ministry of Culture.